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iTIVA is a simulation program that provides information about distribution of drugs based on mathematical models, and it simulate the behavior of a TCI pump (up to 3 drugs at time), obtaining infusion rates to reach and maintain a stable target effect site concentration, those schemes can be implemented in volumetric infusion pumps, and be guided with pharmacokinetics models.
So now pharmacokinetics can become an easy topic and understanding what is going on during a infusion of a intravenous drug, too.

Pharmacokinetic models

iTIVA include 11 drugs and 40 pharmacokinetic models, that are updated continuously:

-Remifentanil
Adults: Minto
, Eleveld, Kim
Kids: Rigby-Jones, Eleveld, Ross

-Fentanyl

Adults: Shafer, Scott

Kids: Ginsberg, Encinas (Neonates)

-Sufentanil

Adults: Gepts, Bovill

Kids: Greely

-Alfentanil

Adults: Maitre

-Ketamine
Adults: Domino, Clements-250

 Kids: Herd, Elkomy

-Procaine
Adults: Seifen

-Lidocaine

Adults: Dyck, Schnider

-Propofol

Adults: Schnider, Eleveld, Marsh, Cortinez

 Kids: Peadfusor, Kataria, Eleveld

-Dexmedetomidine

 Adults: Hannivoort, Dyck, Lin, Venn

Kids: Potts

-Midazolam

Adults: Albrecht, Greenblatt

-Tranexamic

Adults: Grassin-Delyle
Kids: Goobie, Grassun-Delyle

iTIVA also calculate the end tidal (Et) for Isoflurane, Sevoflurane and Desflurane for the MAC age, with the use of the Mapleson equation.

Created by David Ramirez MD, Cali - Colombia. Universidad de Valle. david@itiva.co

• WARNING:

iTIVA is not designed to handle intravenous drugs for individual patients. Its use is limited to educational purposes to demonstrate pharmacokinetic principles when performing intravenous anesthesia. Therefore the user assumes all risks from the use of this application for clinical purposes.
Infusion schemes are obtained from concentrations based on models published in the medical literature; therefore concentrations achieved from these schemes can vary widely, in the same manner for clinical effects.
This application should only be used by people with extensive knowledge in Anesthesiology.

We don't collect any information about you, for more info about our privacy policy, refer to http://itiva.co/privacy.html

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- Modify patient data during a running simulation: double tap on anthropometric values
- NEW PROPOFOL MODEL: Eleveld 2 / BJA - 2018
- TCI algorithm improved
- Corrected minor problem with kataria model

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